Roma will be without Diego Perotti for around three weeks, while Rick Karsdorp has also picked up an injury.
The Giallorossi face Spal at the weekend before welcoming CSKA Moscow in the Champions League next midweek.
Eusebio Di Francesco’s side then travel to face Napoli on October 28, but they’re likely to be without at least two players.
According to Sky, Perotti’s calf injury will keep him out for around three weeks, as he has a lesion to the soleus muscle.
Karsdorp, meanwhile, has a thigh injury and is expected to spend around 10 days on the sidelines.