Auditko o koksu je jinde.

sníh

dnes u pernštejna;)

FAIRIN: stromovka , tam jedou celoročně

Dneska v Jihlavě... asi má poslední výprava letos. Zásoby nějaké jsou a vzhledem k tomu že už začíná v noci mrznout tak už ani holky neporostou, i když pravda pořád tam bylo mnoho prcků které jsem tam nechával, ale když bude mráz nevyrostou :( Dneska mi už hezky cinkaly když jsem je házel do krabičky ale už roztály a hezky si schnou :)

MATT: kdyžtak celý
Psilocybin – Summary of knowledge and new perspectives
Filip Tylš, Tomáš Páleníček, Jiří Horáček
Prague Psychiatric Center, Prague, Czech Republic
3rd Faculty of Medicine, Charles University in Prague, Czech Republic

PALEONTOLOG: takhle lepší? ;))
Acute somatic toxicity of psilocybin
According to a number of toxicological and clinical studies psilocybin has a very low toxicity (Nichols, 2004 and Passie et al., 2002). Psilocybin showed no specific signs of toxicity in the isolated organs (intestine, heart) of rats and pigs (Cerletti, 1958), it is also not neurotoxic (Johnson et al., 2008). Psilocybin LD50 for rats and mice is 280–285 mg/kg, and for rabbits it is 12.5 mg/kg. Psilocin LD50 is significantly lower for mice and rats 75 mg/kg and for rabbits 7 mg/kg (Usdin and Efron, 1972). The LD50/ED50 ratio is 641 according to the National Institute for Occupational Safety and Health Registry of Toxic Effects (compare this with 9637 for vitamin A, 4816 for LSD, 199 for aspirin and 21 for nicotine). Fatalities associated with ingestion of psilocybin containing mushrooms have been described, however these were not linked to direct toxicity of psilocybin but most victims died after jumping out of the window or committing suicide (van Amsterdam et al., 2011). The only reported fatality was described after ingestion of an extreme dose (psilocin plasma level was 4 μg/ml) of Psilocybe semilanceata ( Gerault and Picart, 1996).

A human lethal dose of psilocybin is difficult to estimate, it is clear that it is much higher than the psychoactive dose. One would have to eat approximately 19 g of the pure drug or consume their body weight in fresh psilocybin containing mushrooms to bring on death (www.erowid.org). Doses have not exceeded 0.429 mg/kg in clinical trials (Griffiths et al., 2006), which is approximately 30× less than the LD50 for rabbits.

Theoretically, hypertension and tachycardia may affect predisposed individuals and extremely high doses of psilocybin (several times higher than in clinical trials) can cause coma, hyperthermia, and respiratory failure (symptoms of serotonin syndrome), similar to high doses of LSD (Klock et al., 1975). However, no such case has been reported to-date. During the long history of psilocybin use in the form of hallucinogenic mushrooms there have been no documented cases of somatic toxicity (Hofmann, 2005). Organ damage (e.g. renal failure) only occurs due to confusion between psilocybin mushrooms and other morphologically similar mushrooms (Franz et al., 1996).