EVILMIND:
NESS:
In order to Sanctify your items you have two options:
Pre-torment: After defeating a Lesser Evil in one of the areas they've taken over, there's a chance a portal spawns that takes you to Hadriel where you can use the Heavenly Forge to Sanctify your items free of charge.
Torment: To gain access to the Heavenly Forge during the endgame, you need to gather Heavenly Sigil. These drop from activities involving the Lesser Evils, such as defeating the World Boss Azmodan or looting the Lesser Evil Hoard's after summoning and defeating Azmodan just south of Zarbinzet in Hawezar. The Heavenly Sigil allows you to teleport to and then Sanctify at the Heavenly Forge, which consumes the sigil.