zajimave doporuceni
https://sci-hub.tw/10.1111/j.1745-4565.1982.tb00429.x
IN VITRO EFFECTS OF MONOLAURIN COMPOUNDS ON ENVELOPED RNA AND DNA VIRUSES' JOHN C. HIERHOLZER Respiratory Virology Branch Center for Disease Control Atlanta, Georgia 30333 and JON J. KABARA Department of Biomechanics Michigan State University East Lansing, Michigan 48824 Received for Publication April 13, 1981 Accepted for Publication October 31, 1981
ABSTRACT Monolaurin alone and monolaurin with tert-butylhydroxyanisole (BHA), methylparaben, or sorbic acid were tested for in vitro virucidal activity against 14 human RNA and DNA enveloped viruses in cell cul- ture. At concentrations of 1% additive in the reaction mixture for l h at 23"C, all viruses were reduced in infectivity by >99.9%. Monolaurin with BHA was the most effectiue uirucidal agent in that it removed all measurable infectivity from all of the viruses tested. The compounds act- ed similarly on all the viruses and reduced infectivity by disintegrating the virus envelope