Asi tak :)

FRK_R23: optej se qwwertyho, ja tenhle postup nezkousel, zatim jsem zbytky neresil.

MARASAN: To moc nejde, padaj z toho takový divný bloby a nebo tu mám x nepovedejch tisků :)

FRK_R23: mi se libi QWWERTY :o)

Co děláte se zbytkama?

QWWERTY: tady lze najít koment od spoluautora té studie (Jiří Dejmek), jako tradičně někdo vytrhl informace z kontextu a tvoří paniku. Jasně že je potřeba být opatrný, ale pěstování buněk je něco trochu jiného..

3D tisk
https://www.facebook.com/share/p/1FvEsS7LyJ/

Ahoj, nabizim za 5k mk3s+. Nejake trysky k tomu. Hladky PEI plat. Vse v pohode, dostal jsem mk4s

KAERO: to mas pravdu, viz
"Given the highly manufacturer-, grade-, and pigment-dependent nature of proprietary additive packages, these findings should not be universally generalized to all polymers within these classes."

taky mi prijde zajimave, ze s aktualnimi standardy jsou ok i ty problemove kusy
results expose a critical regulatory ‘blind spot’ in current safety assessments.
We demonstrate that the standard ISO 10993-5 viability threshold (≥70%) is insufficiently sensitive to capture latent, sub-lethal metabolic stress, and that biocompatibility
highlights a critical gap in current regulatory frameworks and underscores the dire need for developing new, metabolically validated reference materials for advanced biocompatibility screening.

QWWERTY: jenze autori nepisou jestli nebezpeci jde z PETG, nebo z aditiv v tom plastu:
"The latent cytotoxicity may stem from the base polymer matrix itself, the complex proprietary mixture of industrial additives (such as plasticizers, stabilizers, and pigments), thermal degradation by-products generated during the extrusion process, or a synergistic effect of these components."
...
"The exact chemical identity of the cytotoxic agents remains unknown."


Takze je klidne mozne, ze filament PETG jednoho vyrobce bude ok, a jineho spatny.
Navic na PETG jdou najit clanky o jeho biokompatibilite, takze bych PETG jako takove nezahazoval.

QWWERTY: Ale to už se psalo před 5 lety, že ty mikročástečky z 3d tisku jsou toxický.

RUTHER: + samotny whitepaper:
Hidden cytotoxicity and mitochondrial dysfunction in 3D-printing polymers: evidence from FLEX, PETG and PC | Scientific Reports
https://www.nature.com/articles/s41598-026-56283-1
evaluated the biological impact of short-term (24 h) and long-term (7 days) exposure to 16 commercially available filaments—representing 8 polymer types (PLA, PETG, CPE, PC, ABS, ASA, PP, and FLEX)—on primary human dermal fibroblasts

significant toxicological paradox in specific commercial filaments tested, such as the evaluated PETG, PC, and PP formulations.
standard ABS and CPE exhibited a high degree of cytocompatibility, maintaining stable metabolic and mitochondrial functions over the entire 7-day exposure period.

most severe manifestation of this hidden toxicity was recorded in the FLEX (TPU) filament, which induced a critical bioenergetic impairment.




docela nestastne s tim PETG, vzhledem k tomu, ze je to v dobre tisknutelny a odolny plast :/

TOM: a proc myslis, ze ten muj predchozi post obsahuje prave z techto duvodu poznamku o customizaci? :))