6.2. Cannabidiol (CBD) and Hair Growth

In a pilot study using ex vivo human hair follicles and primary outer root sheath keratinocytes, CBD showed variable effects on both the elongation and hair cycle of human hair follicles. In that study, the researchers proposed that CBD concentration could lead to differential receptor activation, with a low dose (0.1 μM) favorably affecting hair growth pathways and a higher dose (10 μM) reducing hair shaft development through activating TRPV4 [73].

In a case series, 35 patients with androgenetic alopecia used a once-daily topical hemp oil formulation, averaging 3–4 mg of CBD per day, and reported significant hair growth after six months with no side effects [74]. These findings all suggest that cannabinoids, which interact with TRPV channels, could function as a promising target for human hair growth control.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10672037/

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Mate nekdo zkusenost s tim, ze by CBD pomahalo s rustem vlasu? [Me fakt neprestane udivovat, na co vsechno se ta kytka muze hodit!]

CBD, a precursor of THC in e-cigarettes - PMC
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8076212/

The use of cannabidiol (CBD) in electronic cigarettes is widespread. Previously, it was reported that CBD is partly transformed to THC in case smoking as a cigarette, however, the pyrolysis of this compound has not been assessed extensively. The aim of our study was to investigate the effect of temperature on the composition of pyrolysis products of CBD. The experiments were performed in the typical operating temperature range of e-cigarettes (250–400 °C) and at 500 °C under both inert and oxidative conditions, and the pyrolysis products were identified and quantified by GC–MS. Depending on the temperature and atmosphere, 25–52% of CBD was transformed into other chemical substances: Δ9-THC, Δ8-THC, cannabinol and cannabichromene were the predominant pyrolysates in both conditions, all formed by cyclization reaction. THC was the main pyrolysis product at all temperatures under both oxidative and inert conditions. Our results point out that CBD in e-cigarettes can be considered as a precursor of THC, thus it bears all the dangers related to this psychoactive compound. Our findings are fundamental contributions to the safety profile of CBD-based e-cigarettes.

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Mate nekdo zkusenost s tim, ze kdyz se kouri CBD, ze by bylo omamne kvuli pyrolize na THC? Ja jen vapim.

ZAHRADKAR: poucna je ta zmena kinetiky predevsim okolo 100°C. pri 110 uz je za pul hodiny kyselina v podstate uplne dekarboxnuta, kdezto pri 95 se to k stejnemu procentu nepriblizi ani za hodinu. Za me mi z toho vychazi, ze pri extrakci do tuku nema smysl smes trava+tuk+voda dlouho varit, vyhodnejsi je oddelit cisty tuk a ten pak dekarboxylovat rychlym opatrnym ohratim na 120-130°C

Hledal jsem nejaky zdroj, ktery by popisoval dobu, za kterou jsou kanabinoidy dekarboxilovany v zavislosti na case. A nasel jsem: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5549281/

Pridavam rovnou obrazky - prvni je THC a druhy je CBD. Nahore je vzdy koncentrace kysele formy, pod ni (B) je pak koncentrace dekarboxilovane formy.

https://ethanrusso.org/wp-content/uploads/2024/03/Spindle-Zamarripa-Russo-Vaporized-D-limonene-selectively-mitigates-the-acute-anxiogenic-effects-of-delta-9-tetrahydrocannabinol-in-health-adults-who-intermittently-us.pdf

Results: When d-limonene was administered alone, pharmacodynamic outcomes did not differ from placebo.
Administration of 15 mg and 30 mg THC alone produced subjective, cognitive, and physiological effects typical
of acute cannabis exposure. Ratings of anxiety-like subjective effects qualitatively decreased as D-limonene dose
increased and concurrent administration of 30 mg THC+15 mg D-limonene significantly reduced ratings of
“anxious/nervous” and “paranoid” compared with 30 mg THC alone. Other pharmacodynamic effects were
unchanged by D-limonene. D-limonene plasma concentrations were dose orderly, and concurrent administration
of D-limonene did not alter THC pharmacokinetics.
Conclusions: D-limonene selectively attenuated THC-induced anxiogenic effects, suggesting this terpenoid could
increase the therapeutic index of THC.

V Německu je od 1. dubna legální držení a pěstění konopí. Takto to vypadalo o půlnoci u braniborské brány

ZAHRADKAR: já nad tím už od dopoledne přemýšlím, ta syntetika s 0,11 je fakt zařážející, nějak tak si představuju účinek magnetu na bendera :D

OzChomp Futurama S01E02 - Bender vs Magnets
https://www.youtube.com/watch?v=ZkVkSxBENnU

Dobrý přehled
Molecular Targets of Cannabinoids Associated with Depression - PMC
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9007087/

Hodně mě zaujaly ty affinity k CB1 a CB2 - oproti přirozeným endokanabinoidům je THC pěkný turbo ...