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    ztracené heslo?
    GORGworld conspiracy // 911 // free world order! ... part 5 ::
    Prosím dodržujte formát klubu - posílejte pouze reference (ideálně s copy paste relevantním obsahu) na věci related k topicu.
    Diskuze tu bude mazána. Na to tu není prostor.


    =>
    We cannot trust solutions that are offered by the people who created the problem in the first place.

    Principles for evaluating websites * How to Identify Misinformation

    We shall be slaves as long as we’re convinced that we have masters, and not one moment longer. Whatever must be done, we can do it ourselves. We do not need them; we need each other. All else is distraction and delusion.


  • Demokracie se nejlépe prosazuje v ignorantské společnosti, kterou je možno burcovat, jinými slovy ovládat, nacionalismem a náboženstvím.
  • Taková míra nacionalismu předpokládá existenci permanentní vnější hrozby. Když taková hrozba není, je nutno ji vytvořit.
  • Pravda musí být přísně střežena a tedy známa jen elitě několika vyvolených, kteří společnost řídí.
  • Tato elita musí být připravena říkat nechápavé mase "vznešené lži".


  • General: The Scientific Principles of Spiritual Enslavement (2002), Noel Huntley, Ph.D.
    The Educational System Was Designed to Keep Us Uneducated and Docile
    Silent Weapons for Quiet Wars (EN) :: Tiché zbraně pro klidné války (CZ)
    Blátivé stíny
    Financial: Murray N. Rothbard - What has government done to our money
    Fractional Reserve Banking as Economic Parasitism - Scientific, Mathematical & Historical Expose, Critique and Manifesto - Vladimir Z. Nuri, 62 pg.
    Chcem celú Zem + 5% navyše!
    Michael Rowbotham: Smrteľné zovretie
    Media: Who owns the media
    How To Deal With The Media, The Internet And The New World Order
    new world order in the news...
    Realita - paranoia - dystopie - (fnorDU4ever) * od 1984 do 2012?
    U nas v Kocourkove (und Eine Kleine Mafia) - jak hluboko lze jeste klesnout? - Klub pratel pro znovuoziveni defenstrace
    documents @ conspiracy central :: mvgroup.org :: p2p docs forum :: :: chomskytorrents.org :: indypeer.org

    Jsme zvyklí spojovat slovo teorie se slovem konspirace, protože konec konců žádná konspirace nemůže být reálná, všechno jsou to jen „teorie“, že ano? Nicméně ve spojení „konspirační teorie“ jsou dvě slova, prvním je slovo „konspirace“, druhým slovem je „teorie“. Dle definice je teorie předpoklad, myšlenka, koncept, hypotéza. Dám vám příklad. Teoreticky, pokud si koupím lístek do loterie, mohu vyhrát cenu. Dokud si lístek nekoupím, je má výhra pouze teoretická. Ale jakmile si jej koupím, výhra už není teorií, stává se možností. A čím více lístků si koupíte, tím je zde větší možnost, a eventuálně pravděpodobnost, že se výhra dostaví. Stejně je tomu v případě konspirační teorie. Dokud neexistují důkazy, neexistuje konspirační teorie. Jakmile však máte část důkazního materiálu, a nezáleží na tom, jak je chatrný či podružný, stává se z teorie možnost. A čím více důkazního materiálu je shromážděno, tím zde existuje větší možnost a eventuálně pravděpodobnost, že se jedná o konspiraci.
    V tomto klubu budete sledovat důkazy. A bude na Vás, abyste rozhodli, zda se jedná o konspirační teorii, nebo skutečně o konspiraci.
     
    Clifford Hugh Douglas, jeden z hlavných reformátorov monetárneho systému tridsiatych rokov 20. storočia:
    Jadrom tohto podvodu je tvrdenie, že peniaze, ktoré tvoria, sú ich vlastné, pričom sa od falšovania peňazí nelíši kvalitou, ale iba svojím obrovským rozsahom... Môžem to dokázať mimo akúkoľvek pochybnosť? Podstatou celej záložitosti je nárokovanie si vlastníctva peňazí. Akákoľvek osoba alebo organizácia, ktorá môže podľa ľubovôle tvoriť peniaze ekvivalentné cenám tovarov produkovaných komunitou, je skutočným vlastníkom týchto tovarov a preto nárokovanie si týchto peňazí bankovým systémom je nárokovaním si vlastníctva krajiny.

    Meyer Amstel Rothschild:
    "Give me control of a nation's money and I care not who makes her laws."

    Lord Josiah Stamp, bývalý riaditeľ Bank of England:
    Moderný bankový systém vyrába peniaze z ničoho. Tento proces je azda tým najchytrejším kúzelníckym trikom, aký bol kedy vymyslený. Bankovníctvo bolo počaté v nečistote a zrodené v hriechu. Bankári vlastnia zem. Vezmite im ju, ale keď im ponecháte moc poskytovať úvery, ťahom pera dokážu vytvoriť dosť peňazí na to, aby si ju kúpili naspäť... Ak chcete byť otrokmi bankárov a platiť náklady vášho otroctva, potom nechajte, nech si banky tvoria peniaze.
    Thomas Jefferson:
    Keď americký ľud dovolí bankám, aby mali pod kontrolou vydávanie ich vlastnej meny, najprv formou inflácie a potom defláciou, banky a korporácie, ktoré okolo nich vyrastú, zbavia ľudí všetkého vlastníctva až sa ich deti zobudia a zistia, že na kontinente, ktorý ich otcovia obývali, sú bez domov. Moc vydávať peniaze by mala byť odňatá bankám a navrátená kongresu a ľuďom, ktorým patrí. Som úprimne presvedčený, že bankové inštitúcie vydávajúce peniaze predstavujú pre slobodu väčšie nebezpečenstvo než armády.

    "It (Central Bank) gives the National Bank almost complete control of national finance. The few who understand the system will either be so interested in its profits, or so dependent on its favours, that there will be no opposition from that class... The great body of the people, mentally incapable of comprehending, will bear its burden without complaint, and perhaps without even suspecting that the system is inimical (contrary) to their best interests."
    A Rothschild family communique to associates in New York, 1863

    There are only three types of people in the world:
    1. People who make things happen. 4%
    2. People who watch things happen. 6 %
    3. Sheeple who say, What happened? 90% ->


    >> part 2 >>   *   >> part 3 >> (zde v zahlavi puvodni 'elite search engine')   *   >> part 4 >>


    /
    We shall be slaves as long as we’re convinced that we have masters, and not one moment longer.
    We shall be slaves as long as we
    rozbalit záhlaví
    RIVA
    RIVA --- ---
    KUKIDE: Rikal jsem si ze je to takova prijemna odbocka od serioznosti zivota. Jako si po roce stravovani v menze skocit na hambace a nudle s tatarkou :D
    KUKIDE
    KUKIDE --- ---
    RIVA: riva hele oni jsou natvrdlý nechápou dualitu :D hihihi...
    RIVA
    RIVA --- ---
    Tak to zas jednou trochu rozjedem! :D

    The New Age of Aquarius World Order
    Thread by @JamesPa74499104 on Thread Reader App – Thread Reader App
    https://threadreaderapp.com/thread/1360226676131651584.html

    Discussed in this thread;

    •The imminent mass culling of humanity

    •Why the Elites want 'Truthers' to survive this cull for the main event in 2025

    •The coming Luciferian One World Religion
    RIVA
    RIVA --- ---
    Prof Desmet - failure of science today - July 30 2021
    https://odysee.com/@shortXXvids:e/Desmet-extraxt-3---Problems-in-science:5?

    In this short extract from a one hour session, Mattias Desmet, Professor of Clinical Psychology at Ghent University, discusses with the German Corona Committee why most scientific conclusions of today cannot be trusted. More on www.corona-ausschuss.de
    RIVA
    RIVA --- ---
    RIVA:

    Noosphere, Part II: Atheistic Mythologies

    In spite of their great diversity, the myths that serve as the foundational elements of the noosphere can all be sorted into categories identified by a member of the following set: {NULL, 0, 1, 2, 3}. These identifiers indicate atheistic, polytheistic, monistic, dualistic and trinitarian mythologies. These numbers do not obey the laws of arithmetic but behave in the following counterintuitive and non-obvious ways:

    Atheistic: NULL is NULL
    Polytheistic: 0 = ∞
    Monistic: 1≠1
    Dualistic: 1+1=1
    Trinitarian: 1+1+1=1

    As promised, we shall now look at each one of these. This week's installment will address atheistic mythologies.

    Atheistic mythologies

    NULL is NULL is NULL. NULL is different from zero: zero means that there is nothing there; NULL means that we neither know or care what's there. NULL is not equal to anything—not even to itself, since there are no grounds for comparison; therefore, all that can be said about it is that it is NULL—a tautology. There is an almost limitless variety of adherents of NULL, just as there is an almost limitless variety of broken pottery in the world's landfills, dumps and middens, but a particularly pervasive example is Homo trivialis: the degenerate case of a non-sapient Homo sapiens, a man unconcerned with anything more lofty than a full belly, a satisfied libido and a warm, dry place to sleep. The typical Homo trivialis specimen is a satisfied consumer of sudsy beer, starchy and fatty foods and television sports. Or it might be a woman, her concerns laser-focused on her hair, nails and shoes, with surgically enhanced breasts, lips and buttocks as added extras.

    Also among the adherents of NULL are the technosphere's eager minions. These are the technophiles who see anything beyond a purely mechanistic conception of the universe as base superstition to be ridiculed, whereas his own idolizing and fetishizing of technology is not ridiculous at all, mind you! Several generations of science fiction writers have constructed an entire technospherical universe which you can traverse aboard the good little spaceship Spinal Tap which goes Warp 11 (but only in your juvenile imagination). In reality humans have never so much as poked their heads outside of low Earth orbit, all of the Apollo mission nonsense notwithstanding, and probably never will. It now turns out that Americans can't go back to the moon because they don't have the spacesuits. Those wonderful spacesuits they used to romp around on the Moon were gnawed to pieces by some space rats and they can't make new ones because they lost the blueprint and then their dog ate it. This is all highly believable, of course, but only if you are gullible as a child.

    Among the adult population, there is also some number of philosophical rationalists. They are convinced that an entity whose existence cannot be proved (documented, attested, weighed, measured, made to pee into a cup, interviewed on camera, dragged into court to testify, etc.) does not exist. This stance is particularly humorous if approached from the point of view of a deity: if I were God (which, by the way, I am not; this is purely a thought experiment) then why would I condescend to being trifled with in this manner? As God, I would be well-disposed toward those who believe in Me and worship Me, perhaps even showing Myself to them, but only in purely mystical, ethereal ways so as not to trivialize my godlike nature. But I would mostly ignore those who don't believe in Me and don't worship Me as long as they leave My true believers alone. But I would strike down with great vengeance and furious anger those who attempt to poison and destroy My brothers. That part Ezekiel [25:17] got right. But they would not know that My name is the Lord when I lay My vengeance upon them; rather, they would not know what hit them and simply call it an "act of God" (in Whom they don't believe). I am done speaking as God now, fun though that is.

    From the point of view of the technosphere, these are all ideal clients: either they are indifferent, obedient and easy to manipulate, with no agenda of their own, or they are zealous guardians of the technosphere who wish to technologize everything and would eagerly climb into a space capsule and be shot off into the endless emptiness of space just for the greater glory of it.

    Passionate, zealous adherents of NULL are the technosphere's most faithful servants. Their insistence that everything must have a rational basis is very helpful in enlarging the technosphere's scope and enhancing its ability to achieve total control over humanity. A rational approach is, of course, often helpful, especially when deciding how much water to put in a nuclear reactor to keep it from melting down. But it is neither necessary nor sufficient in finding life's meaning; quite the opposite, it is quite helpful in destroying it. The technosphere's long-term goal, then, is to drive all of humanity toward the NULL state.
    ARRAKIS
    ARRAKIS --- ---
    Australia Rethinks Covid Strategy After Cases Hit Record Despite Draconian Lockdowns | ZeroHedge
    https://www.zerohedge.com/covid-19/australia-rethinks-covid-strategy-after-cases-his-record-despite-draconian-lockdowns



    RIVA
    RIVA --- ---
    The Role of Central Banks in the COVID Crisis - Prof. Richard Werner & Catherine Austin Fitts
    https://youtu.be/EpukkSaiAX0
    RIVA
    RIVA --- ---
    GORG
    GORG --- ---
    Švajčiarski policajti už nechcú mlčky presadzovať obmedzujúce covidové opatrenia
    https://www.infovojna.sk/article/svajciarski-policajti-uz-nechcu-mlcky-presadzovat-obmedzujuce-covidove-opatrenia

    Vo Švajčiarsku sa policajti zo všetkých kantónov spojili do združenia „My pre vás“ a napísali list Policajnému zväzu. Nie sú už ochotní mlčky a bez odporu presadzovať covidové opatrenia.

    Über uns | wirfuereuch.ch
    https://wirfuereuch.ch/aboutus/

    We are an association of police officers from all cantons in Switzerland. In addition, we have committed ourselves to the democratic constitutional state to protect and uphold the fundamental rights of everyone to the best of our knowledge and belief. However, we are increasingly observing negative developments within society, especially in direct contact with the population. We are also affected as private individuals, as fathers and mothers, brothers and sisters, sons and daughters. We see the restrictions on fundamental rights to this extent and over the previous period in contradiction to proportionality and the greatest good of a democracy: freedom. The question arises as to what justifies these restrictions. These questions need to be answered.

    The need to express one's opinion freely is very great among our professional colleagues. We offer a platform where you as a police officer can report without fear of exclusion or consequences.

    Letter to the VSPB
    MTO
    MTO --- ---
    RIVA
    RIVA --- ---
    7 lies about Afghanistan, by Thierry Meyssan
    https://www.voltairenet.org/article213772.html
    RIVA
    RIVA --- ---
    Joe Biden's fight for «Democracy», by Thierry Meyssan
    https://www.voltairenet.org/article213771.html
    RIVA
    RIVA --- ---
    Smart Cities & the End of the Era of Man — Strategic Culture
    https://www.strategic-culture.org/news/2021/08/20/smart-cities-end-of-era-of-man/
    RIVA
    RIVA --- ---
    RIVA
    RIVA --- ---
    Dmitry Orlov:

    The Technosphere and the Noosphere of the Earth
    In my 2016 book Shrinking the Technosphere I described the technosphere as a nonhuman global emergent intelligence driven by an abstract teleology of total control, a networked machine with some human moving parts (fewer and fewer every day), utterly devoid of any moral or ethical sense (but skilled in using morality and ethics for manipulative purposes). The technosphere can keep you alive and comfortable if it finds you useful but can just as easily kill you, its killing technologies being some of the most advanced. I made the case that we ought to work diligently on shrinking the technosphere; not eliminating technology altogether, mind you, since that would spell the death of billions, but reigning it in and becoming the master of it rather than it being the master of us.

    My book did define half the problem but, concentrating as it did on technology alone, it ignored the other half by placing an important question—What drives the totality of the human endeavor?—out of scope. Yes, the technosphere doesn't particularly care whether we live or die. If we must shrink the technosphere, then to what purpose? The technosphere is powerful, and to wage battle against it requires some measure of heroism and wild abandon. But what is to motivate us to become heroes—fear of death? Well, fear has never produced a hero. Why try to be a hero if mere cowardice can produce similar results?

    What can control and shrink the technosphere is not you or me and our puny and pathetic efforts but cultural and civilizational forces beyond our control. In order to understand them, we first have to admit that nothing is out of scope. We need to start by examining the variety of religious mythologies that serve as the basis for most human motivations. Some of them constrain the technosphere in purposeful ways while others allow it to run rampant. These mythologies, along with everything that is built up on top of them, comprise the noosphere of the Earth, which I will attempt to describe.

    The world has changed appreciably in the intervening years since I published this book, specifically in the direction of total control of the technosphere over our lives. Much of the world's population is now being ordered about, often seemingly at random, injected with experimental concoctions with unknown long-term consequences, forced to self-isolate and wear face masks. A certain not particularly lethal, quite possibly artificial respiratory virus has provided a convenient excuse—all to mask dire developments in the availability and affordability of fossil fuels. In many parts of the world basic human freedoms have all but evaporated: people now live in a panopticon, continuously observed and monitored for signs of disobedience by their computers and smartphones, ubiquitous security cameras, their public speech censored by artificial intelligence algorithms. It would seem that we now live in a technological anti-utopia that would surprise both Orwell and Huxley. The technosphere appears to have won; as of 2021, little stands in its way of sidelining the wise and old, brainwashing the young and foolish and replacing humans with widgets.

    What I proposed in that book didn't work, but I have since learned enough to try to fix the problem, at least from the point of view of understanding it better. To do this, we first have to zoom out and place the concept of the technosphere within its proper context. The technosphere is but one aspect of a larger intellectual scheme created by the Russian scientist Vladimir Vernadsky, a luminary of 20th century science who founded entire new scientific disciplines—biochemistry and radiogeology—and was one of the founders of genetic mineralogy and geochemistry. None of the other 20th-cenury scientists could compare with him in his breadth of knowledge. The pinnacle of his creativity was his teaching about the biosphere—a result of synthesis of ideas and facts from tens of different branches of natural science. Vernadsky was a student of Dmitry Mendeleev, who, with his invention of the Mendeleev Table, founded modern chemistry. Vernadsky was, in turn, the teacher of Igor Kurchatov, the nuclear scientist who, among others, provided the USSR with the nuclear deterrent that saved it from annihilation by the USA, which it planned to carry out in the years following its successful atomic bombing of Japan.

    These shining beacons of world science have been steadfastly ignored in the West. Mendeleev's contribution is impossible to ignore, and so Mendeleev's Table has been coyly renamed "The Periodic Table of Elements" while Vernadsky is hardly mentioned at all. And yet it is Vernadsky who provided the best conceptual framework for understanding life on Earth and humanity's place within it—much better than James Lovelock's amateur theologizing of an entirely imaginary and in its latest iteration supposedly vengeful Gaia. But Gaia is politically useful in threatening to unleash its sweet vengeance on anyone who dares to track carbon footprints across her sitting room rug.

    Let's look at Vernadsky's model, which encompasses pretty much all that should ever concern us. Omitting some details, Earth is a ball with a solid iron core surrounded by molten or semi-molten mantle of silicate rock upon which floats a thin crust made up of lighter stuff that makes up the ocean floor and the islands and continents we inhabit. Nuclear fission reactions within Earth generate heat which is dissipated through volcanism, tectonic plate movement and the warming of the oceans from the bottom up. Amusingly, the agenda-driven scientists of the Intergovernmental Panel on Climate Change have consistently flubbed even the simplest Earth science quiz, claiming that melting glaciers will cause sea levels to rise, neglecting to notice that both the land on which the glaciers rest and the ocean floor which their meltwater would push down are afloat. If the land ice melts and runs off into the oceans (a process that would take up to a million years) earthquakes would cause the land would rise and the sea floor to fall, negating the effect.

    The biosphere (a term coined by Vernadsky) is a sphere located between the uppermost layers of Earth's crust and the lower reaches of the stratosphere where all the living things are, while areas both above and below are entirely bereft of life. But that's not all that's going on. Since Homo sapiens evolved, the biosphere has been increasingly transformed by the effects of two more spherical entities: the noosphere (from the Greek nöos, knowledge or wisdom)—a sphere of human knowledge. The noosphere is what makes Homo sapiens sapient. There is also the technosphere (also a Vernadsky coinage) which encompasses the ever-growing grab-bag of technical tricks available to all Homo sapiens regardless of their noospheric differences and which has increasingly developed a primitive mind and an agenda of its own.

    For both the biosphere and the noosphere, diversity is key. Bombard Earth with asteroids or nuclear bombs, cover it with volcanic ash from nuclear eruptions, subtly alter its atmospheric chemistry by burning every bit of fossil fuel you can get your hands on—and it will bounce back, eventually, because once the dust settles some organisms that were previously lurking in the shadows will float up from the depths of the ocean or crawl out of some crevice and evolve to fill every newly available niche. Similarly with the noosphere: a certain set of myths (capitalism, communism, socialism, democracy, progress, climate catastrophism, universal human values, etc.) may flourish for a time, then perish, and other, perhaps newer, but most likely older myths will step out of the shadows and take their place.

    If you imagined that the noosphere encompasses what you know or consider to be common knowledge in some officially, internationally recognized sense, you would probably be wrong. The noosphere is a stack that includes social relationships, political traditions, history, language, local custom and law, traditions, religious observances and at its foundation lie religious myths that give life meaning. Walk up to a random person and ask: "What is your life's purpose?" If the answer is along the lines of "Work and play well with others" or "Get rich and have sex with lots of strangers" or "Make enough to feed my family" than the Homo sapiensyou are talking to may not be particularly sapient, since the same motivations might drive an ape, an elephant, a penguin or even a termite. A more interesting answer would be more along the lines of "Become one with my spirit animal" or "Enter into the Kingdom of Heaven" or "Break the cycle of death and resurrection by reaching nirvana."

    In spite of their great diversity, the myths that serve as the foundational elements of the noosphere can all be sorted into categories identified by a member of the following set: {NULL, 0, 1, 2, 3}. These identifiers indicate atheistic, polytheistic, monistic, dualistic and trinitarian mythologies. These numbers do not obey the laws of arithmetic but behave in the following counterintuitive and non-obvious ways:

    Atheistic: NULL is NULL

    Polytheistic: 0 = ∞

    Monistic: 1≠1

    Dualistic: 1+1=1

    Trinitarian: 1+1+1=1

    Next week, we shall look at each one of these.
    RIVA
    RIVA --- ---
    Dr Charles Hoffe - Vaccinated Likely To Be Dead Within 3 Years
    https://www.bitchute.com/video/Gm7VLbzafzn1/
    RIVA
    RIVA --- ---
    cryptogon.com » Australia: ABC TV Newscast Interrupted by Clip of Satan Worshipers
    https://www.cryptogon.com/?p=62073
    KUKIDE
    KUKIDE --- ---
    RIVA: celkem nic novýho pod sluncem ... to že se tahle technologie dá použít, teda spíše zneužít je jasný... ale popravdě jim to moc nebude fungovat... každej kdo má děti mi jistě dá zapraavdu :D
    RIVA
    RIVA --- ---
    Peter Gumley on Boris Johnson, the British Deep State and the American Empire | Free Podcasts | Podomatic"
    https://www.podomatic.com/podcasts/tkelly6785757/episodes/2021-08-16T13_47_56-07_00
    RIVA
    RIVA --- ---
    iPhone Neural Hash - SHOCKING AI Tech
    https://odysee.com/@RobBraxmanTech:6/apple:8
    RIVA
    RIVA --- ---
    COPTIGATE - THE WORST DESIGN FLAW IN HUMAN HISTORY THAT IS IMPACTING YOUR HEALTH
    Thread by @eh_den on Thread Reader App – Thread Reader App
    https://threadreaderapp.com/thread/1426885632140394499.html

    #COptiGate

    (thread)
    How come Prizer, Moderna, AstraZeneca, Janssen etc. are using a technology that both they and the regulators know will cause unknown results?
    (plus a bonus)



    Image
    Let's start with a thought experiment:
    If an engineering design flaw exists and no one measures it, can it really injure people or kill them?

    Making a new vaccine is hard. Making a new vaccine that uses a new technology is even harder, because you need to prove safety.

    Luckily, when it comes to COVID, the vaccines have been tested and shown to be safe, right?

    Well, they might have forgotten one thing...

    Trying to tell your body to generate proteins is hard for many reasons. One of them is the fact that when you try to run the protein information via ribosomes which process that code and generate the protein, it can be very slow or can get stuck during the process.

    Luckily, scientists found a way to overcome this problem, by doing code substitution: instead of using the original genetic code to generate the protein, they changed the letters in the code so the code would be optimized. This is known as Codon Optimization.

    Codons are three nucleotides; nucleotides are the building blocks of your DNA.

    Here is an example of Codon Optimization:
    60% of the codons were altered,
    22% of the nucleotides were altered.

    And yet the end result is that the ribosomes generate the same protein!



    Same? Well, not so much.

    In 2011 Nature Medicine magazine published an article called "Breaking the Silence". It described how codon optimization, which uses this synonymous DNA changes, can trigger disease in a number of ways.

    Breaking the silence | Nature Medicine
    https://www.nature.com/articles/nm1211-1536



    Turns out the protein which was manufactured when codon optimization has different ways it folds and a different 3D shape, and it "could cause immunogenicity, for example, which wouldn’t be seen until late-stage clinical trials or even after approval".



    "The changed form could cause immunogenicity, for example, which wouldn’t be seen until late-stage clinical trials or even after approval." (Chava Kimchi Sarfaty, FDA)
    This statement relates to the NORMAL approval cycle. The COVID vaccines went via an accelerated one.

    "codon optimization can lead to alterations in protein conformation and function…. and increase immunogenicity….some of these elements can … alter protein folding, and lead to changes in protein conformation and post-translational modifications.” (Vincent P. Mauro)

    Protein misfolding "has been linked with neurodegeneration in Alzheimer and Parkinson disease, and many other pathologies."

    Protein Misfolding Diseases - PubMed
    https://pubmed.ncbi.nlm.nih.gov/28441058/

    "The data confirm that protein misfolding resulting in intracellular PAO accumulation is sufficient to cause cardiomyocyte death and heart failure."

    Protein misfolding and cardiac disease: establishing cause and effect - PubMed
    https://pubmed.ncbi.nlm.nih.gov/18612262/

    So if it is so problematic, why do manufacturers use it? because "higher levels of protein expression are required for clinical trials and commercialization, and these expression levels can sometimes be obtained by using (codon optimization)" (Vincent P. Mauro, 2018)

    Pfizer is the most aggressive in their genetic code optimization (as far as we know); just read the abstract from "BNT162b2 Vaccine: Possible Codons Misreading, Errors in Protein Synthesis and Alternative Splicing's Anomalies"

    BNT162b2 Vaccine: possible codons misreading, errors in protein synthesis and alternative splicing's anomalies - Authorea
    https://www.authorea.com/users/348455/articles/503889-bnt162b2-vaccine-possible-codons-misreading-errors-in-protein-synthesis-and-alternative-splicing-s-anomalies?commit=c216b0c03c51c8776a81ea85c76429376b5eb3b1



    Do they mention it to the regulator? no.
    Here is Pfizer BNT162b2/Comirnaty Risk Management Plan for the EMA.

    Variant V8 & V9 were tested, only difference was codon optimization, V8 had elevated levels of gamma-glutamyl transferase (GTT), V9 didn't.





    So Pfizer admits codon optimization can lead to elevated GTT, and "elevated GGT is linked to increased risk to a multitude of diseases and conditions, including cardiovascular disease, diabetes, metabolic syndrome (MetS), and all-cause mortality."

    Gamma-Glutamyltransferase: A Predictive Biomarker of Cellular Antioxidant Inadequacy and Disease Risk
    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4620378/

    And even though Pfizer admits codon optimization impacts the safety of their product, "Safety pharmacology, genotoxicity and carcinogenicity studies have not been conducted in accordance with the 2005 WHO vaccine guideline."

    How did they manage to avoid testing?



    The WHO 2005 document states that such tests normally not needed for the FINAL vaccine formulation. This is because in a NORMAL vaccine approval pharmacology, genotoxicity and carcinogenicity studies are done during ANIMAL STUDIES, which were practically skipped here.



    Even though EMA states:
    "It is important to investigate the potential for undesirable pharmacological activity in appropriate animal models and, where necessary, to incorporate particular monitoring for these activities in the toxicity studies and/or clinical studies"




    Back to sequencing: this concern was reported in 2006, published in 2007, and "breaking the silence" was published in Nature Medicine magazine in 2011, the FDA or its equivalent in Europe (EMA) STILL THEY DO NOT HAVE a guidance with regard to the genetic sequencing.

    Here is Katerina Alexaki from the FDA explaining how a SINGLE synonymous mutation (mutation that doesn't impact the protein but its 3D object & folding) can result in a disease and that if you have multiple substations there is a good chance it may have an effect:

    https://video.twimg.com/ext_tw_video/1426852651757670404/pu/vid/640x360/tZFo5_kEIo9LcL4K.mp4?tag=12

    Here is again Katerina Alexaki, this time answering the question whether the regulator demand the manufacturers to test for the impact of their codon optimization.
    The answer is no:

    https://video.twimg.com/ext_tw_video/1426853749243486211/pu/vid/1280x720/lurPpwkgT-70_bdo.mp4?tag=12

    Here is a slide from a workshop given to the EMA in 2016, by FDA employee ("Immunogenicity of Biological Therapeutics Product Quality Attributes")
    Construct design affects product quality and "Codon optimization and protein folding" are mentioned.




    The manufacturers knows about the potential risk.
    The regulators knows about the potential risk.

    Yet regulators don't test V products as gene therapy, and do not put in place codon optimization risk mitigation plan.

    IF YOU DON'T MEASURE RISK IT DOESN'T GO AWAY.

    THE BONUS !!!

    Could it be that the "variants" that we see are a result of the misfolding of the spike protein, which is a result of the codon optimization technology used?

    Could it explain the correlation between vaccinations campaigns & "new variants" outbreaks?

    If codon optimization is causing "new variants" (new symptoms & sickness), than any new product (eg boosters) which will include new codon optimized genetic code, will again lead to more forms of sickness.

    PS:
    Where is the 3D model of the "Delta variant"?

    Protein folding is governed by Gibbs Free Energy (ΔΔG). Protein stability seems to plays a vital role in the evolution of SARS-CoV-2. Dominant variants were found to exhibit significantly lower ΔΔG, with HIGHER THAN EXPECTED protein stability.

    https://www.biorxiv.org/content/10.1101/2021.06.25.449882v1.full.pdf

    Just to explain the above, out of the variants of concern, NONE of the dominant mutations (67 of 19440 possible mutations) observed in induce a strongly destabilizing, which was significantly different to the expected 34% of possible mutations meeting this threshold.

    "We suggest that protein folding calculations offer a useful tool for early identification of advantageous mutations"

    Could it be that manufacturers used codon optimization and protein folding calculations in order to stabilize the selected spike protein?

    "hold on, that's the spike protein, that does not explain the spread of the virus. The spike protein is not supposed to replicate!"

    Agreed, but it does not explain IgG antibodies against the nucleocapsid in vaccinated non-infected people.

    Circulating Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Vaccine Antigen Detected in the Plasma of mRNA-1273 Vaccine Recipients | Clinical Infectious Diseases | Oxford Academic
    https://academic.oup.com/cid/advance-article/doi/10.1093/cid/ciab465/6279075




    And for anyone who is still not freaked out...I forgot to mention reverse transcription, thank you @HiveAnti for reminding me.

    "Breaking Study Sheds More Light on Whether an RNA Vaccine Can Permanently Alter DNA".

    Breaking Study Sheds More Light on Whether an RNA Vaccine Can Permanently Alter DNA – Science with Dr. Doug
    https://sciencewithdrdoug.com/2021/02/15/breaking-study-sheds-more-light-on-whether-an-rna-vaccine-can-permanently-alter-dna/

    COPTIGATE REDUX - MAJOR UPDATE!

    The following tweets are A MAJOR REVISION / UPDATE to the story. It's darn complex.
    As the doctor always says in the joke: "I've got some good news, and I've got some bad news."
    Don't worry, you will get ANOTHER BONUS at the end !!!

    Let's start with the GOOD news:
    MOST pharmaceutical companies realized they have a problem (Actually since the MERS outbreak). The spike protein was unstable, so this time they inserted genetic code to create a supportive "skeleton" structure.

    This is how it works:
    They made two substitutions in the genetic code, adding two molecules of amino acid called proline, in order for it to act as an anchor to keep the protein structure in place. I say some MOST because AstraZeneca didn't... Problems solved, right?

    Obviously not (BAD NEWS)!
    So it seems that ALL the vaccines that are in the market who use this technology, known as S-2P or 2P, suffer from instability and it is difficult to produce reliably in mammalian cells. Just a reminder - we are (still) mammals.

    Also, remember - we have TWO substitutions here. If ONE synonymous mutation can lead to a disease, what is the impact of TWO substitutions? The new suggested structure, HexaPro, uses 6 substitutions. Great for performance and stability, but what about safety?



    A tak dal... Ted jsem si uvedomil ze nacpat sem cely clanek by mi trvalo cely den. Na coz nemam bunky. Takze zbytek zde:
    Thread by @eh_den on Thread Reader App – Thread Reader App
    https://threadreaderapp.com/thread/1426885632140394499.html
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