Jo jinak ja ten puvodni prispevek projistotu schovam, za me je “viry” zraly na unbook, jak tam lajkujou burkhari a dalsi “hledaci uzitecnych infoRmaci”, kteri Rikaji European Respiratory Journal, potazmo Nature. Wikipedia, tam uz asi fakt nic chytreho nevypadne.
A to ja jsem se treba jako knihovnik ucil, ze na Internetu vlastne neni nic moc vedecky uzitecneho a cilem je dostat se k citovanym a impactovanym vedeckym clankum ve specializovanych journalech, a kdo je ma, tak je bohaty vsim vedomim sveta a to uz od Issaca Newtona; taky jsem delal pro Wolters Kluwer, ktery vlastni vedu tak do 1945, a pozdej stafetu prebral Elseweer; a ted vetsinu veci jde ukrast na sci-hub; uz proto, ze je tam taky kazdy vedec rad da, pac bez toho by si financne nemoh dovolit byt vedec....
Takze 2 fulltexty, ktere asi zmizi z Viry, cimz to zkonci tak, ze audit unbooknu; a to ne z urazene pycgy, ale proto, ze ct24 si muzu pustit i sam, mozna si poslu Burkyho pro pivo
vyzkum
#fulltexty
Nikdo mi zda se neveri na tema poskozeni plic a skupiny vitaminu B3, jak jsem odkazoval z Nature, kde doporucuji vitamin B3 jako ucinnou prevenci a pomoc i ve vysokych stadii poskozeni plic, tak tady si dovolim 2 fulltexty, je jich vic, ale klicova slova a DOI uz si dohleda, kdo potrebuje a vyuzije lip
To je ten clanek, o ktery se opiraji v Nature
https://moscow.sci-hub.tw/3442/ab5123c4877346f6a85d097a427ef2a5/nagai1994.pdf
Tenhle je offtopic jen vzdalene, spis vubec... viz anotace:
Nicotinamide abrogates acute lung injury caused by ischaemia/reperfusion
C-F. Su, D. D. Liu, S. J. Kao, H. I. Chen
European Respiratory Journal 2007 30: 199-204; DOI: 10.1183/09031936.00025107
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Abstract
Poly (ADP-ribose) synthase or polymerase (PARS and PARP, respectively) is a cytotoxic enzyme which causes cellular damage. Nicotinamide, a compound of vitamin B complex, has been reported to exert an inhibitory effect on PARS or PARP. The present study tests the effects of nicotinamide on acute lung injury and associated alterations following ischaemia/reperfusion (I/R) of the isolated perfused rat's lung.
I/R increased the lung weight (LW) to body weight ratio, LW gain, protein and dye tracer leakage, pulmonary arterial pressure and capillary permeability. The insult also increased nitrate/nitrite, methyl guanidine, tumour necrosis factor-α and interleukin-1β in lung perfusate, while it decreased adenosine triphosphate content with an increase in PARP activity in lung tissue.
Most of the I/R-induced changes were abrogated by post-treatment (30 min after I/R) with nicotinamide (100 mg·kg−1 body weight). However, the increase in pulmonary arterial pressure was enhanced by nicotinamide post-treatment. Following I/R, the inducible nitric oxide synthase (iNOS) mRNA expression was enhanced. Nicotinamide reduced the iNOS expression.
The results suggest that nicotinamide exerted a protective effect on the acute lung injury caused by ischaemia/reperfusion. The mechanisms may be mediated through the inhibition on the poly (adenosine diphosphate-ribose) polymerase activity, inducible nitric oxide synthase expression and the subsequent suppression of nitric oxide, free radicals and pro-inflammatory cytokines with restoration of adenosine triphosphate.
https://moscow.sci-hub.tw/3933/be1d244cbd14875912b0fa84f97756ba/su2007.pdf