ne ze bych to plne chapala, repost z FB, zni DOST zajimave
Na molekulární úrovni je lepší mít smysl života a pomáhat lidem kolem sebe, než si jen užívat.
Vědecké potvrzení, že svět je lepší, než je?!
#eudanism healthier than #hedonism
http://m.pnas.org/content/early/2013/07/25/1305419110.full.pdf?with-ds=yes
To identify molecular mechanisms underlying the prospective
health advantages associated with psychological well-being, we
analyzed leukocyte basal gene expression profiles in 80 healthy
adults who were assessed for hedonic and eudaimonic well-being,
as well as potentially confounded negative psychological and
behavioral factors. Hedonic and eudaimonic well-being showed
similar affective correlates but highly divergent transcriptome
profiles. Peripheral blood mononuclear cells from people with
high levels of hedonic well-being showed up-regulated expression
of a stress-related conserved transcriptional response to adversity
(CTRA) involving increased expression of proinflammatory genes
and decreased expression of genes involved in antibody synthesis
and type I IFN response. In contrast, high levels of eudaimonic
well-being were associated with CTRA down-regulation. Promoter-based bioinformatics implicated distinct patterns of transcription factor activity in structuring the observed differences
in gene expression associated with eudaimonic well-being (reduced NF-κB and AP-1 signaling and increased IRF and STAT signaling). Transcript origin analysis identified monocytes, plasmacytoid
dendritic cells, and B lymphocytes as primary cellular mediators of
these dynamics. The finding that hedonic and eudaimonic well-being engage distinct gene regulatory programs despite their similar
effects on total well-being and depressive symptoms implies that
the human genome may be more sensitive to qualitative variations
in well-being than are our conscious affective experiences.