tak jsme se za tech par let trochu posunuli
bohuhell, jde to pomalu
ale vypada to, ze to pujde vyresit
snad se neurazite za AI, ale opisovat to nebudu :)




The field has moved significantly since the NMN / NAD hype era (~2018–2020) — but not in the direction most hype implied.
It shifted from metabolic supplements to cellular reprogramming — a fundamentally different, much deeper intervention.

Below is a clean map of who is actually doing serious work, what has been proven in mice, what is in humans now, and where Sinclair fits today.

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1) The Core Shift Since the NMN Era

2018–2020 (NMN / resveratrol era)
Focus: metabolism, sirtuins, supplements
Expectation: slow aging

2021–2026 (reprogramming era)
Focus: resetting cell identity and epigenetic state
Expectation: partial rejuvenation of tissues

This is not incremental — it is a paradigm shift.

The current dominant idea:

Aging = epigenetic information loss
Therapy = restore that information

Partial reprogramming using OSK / Yamanaka factors is now the central technology.

These factors can:

* reset DNA methylation patterns
* restore tissue function
* partially reverse biological age markers

This has been repeatedly demonstrated in animals. 

⸻

2) The Most Important Animal Results (Real Ones)

A) Very old mice — lifespan extension after treatment

One widely cited experiment:

* mice equivalent to ~80-year-old humans
* gene therapy delivering OSK factors
* cyclic activation

Result:

remaining lifespan increased ~109%

Not total lifespan — remaining lifespan.
Still significant.



⸻

B) Systemic OSK delivery — functional rejuvenation

Observed in mice:

* improved frailty score
* improved tissue function
* reset epigenetic markers



⸻

C) Tissue-level rejuvenation

Seen repeatedly in mice:

* muscle repair improved
* inflammation reduced
* metabolic function improved



⸻

Important reality check:

Some studies showed:

* biological markers improved
* function improved
* lifespan not always extended



So the effect is real — but not magical.

⸻

3) The Major Companies Working on This (2025–2026)

These are the serious actors — not supplement brands.

⸻

ALTOS LABS

Founded: 2022
Funding: ~ $3 billion

Investors:

* Jeff Bezos
* Yuri Milner



Focus:

* cellular rejuvenation
* organ regeneration
* partial reprogramming

Scientific lead:

Juan Carlos Izpisua Belmonte
(one of the pioneers of the field)

⸻

LIFE BIOSCIENCES

(Sinclair’s company)

This is the most advanced clinically.

Key milestone:

First human trial of epigenetic reprogramming approved in 2026



Technology:

* OSK gene therapy
* localized to the eye

Purpose:

Treat optic nerve degeneration.

Not anti-aging yet — disease-specific.

⸻

REJUVENATE BIO

Focus:

* lifespan extension
* cardiac and metabolic aging

They published:

partial reprogramming extended lifespan in aged mice



⸻

NEWLIMIT

Different approach:

* machine-learning-guided reprogramming
* small-molecule or gene payload discovery

Goal:

Restore youthful cell function in:

* liver
* immune system
* vasculature



They are preparing early human trials in coming years.



⸻

RETRO BIOSCIENCES

Focus:

* multi-organ rejuvenation
* cell reprogramming platforms

Less public data, but significant funding.

⸻

4) Where Human Trials Actually Are (2026)

This is the current frontier.

First true epigenetic reprogramming therapy

Company:

Life Biosciences

Drug:

ER-100

Mechanism:

* delivers OSK transcription factors
* resets epigenetic patterns



Status:

Phase 1 human trial

Goal:

Safety.

Not rejuvenation.

⸻

Key point:

This is the first time in history such therapy entered human testing.



⸻

5) Where David Sinclair Actually Is Now

Your skepticism is shared by many scientists.

Important facts:

He remains influential — but controversial.

Recent issues:

He overstated claims about a supplement reversing aging in dogs and later corrected the wording.



Current role:

* founder of Life Biosciences
* still active in reprogramming research



He is no longer the center of the field.

The center moved to:

* Altos Labs
* industrial biotech
* large translational programs

⸻

6) Where We Are Compared to NMN Hype

Here is the honest comparison.

Era Intervention Evidence strength Real impact
NMN / resveratrol metabolic supplements weak–moderate small
Rapamycin mTOR inhibition strong in animals moderate
Senolytics removing old cells moderate targeted
Reprogramming reset cell state strong in animals potentially transformative

Reprogramming is the first approach that:

* directly targets aging mechanism
* reverses cellular state
* restores function

Not just slows decline.

⸻

7) Timeline — Realistic

Based on current development speed:

2026–2028

Early safety trials
Localized treatments (eye, liver)

2030–2035

First approved disease therapies

2035–2045

Broader rejuvenation therapies possible

This is the consensus trajectory in biotech.

⸻

Bottom Line

The field is no longer hype-driven supplement science.

It is now:

serious gene therapy and cell engineering

What is real today:

* Rejuvenation works in mice
* Multiple companies are investing billions
* First human trials started in 2026

What is not real yet:

* whole-body rejuvenation
* safe systemic reset
* consumer-accessible therapy

The technology is credible.
The timeline is still long.

POZITRON: hele intermittent fasting ti vetsinou zpusobi caloric restriction, ale neni to to samy

to druhy je proste ze min jis a jestli to je tim, ze zeres min

tam je akorat problem kdyz jis kazdej den stejne a je to malo, tak se telo prizpusobi a zacne ti bejt nahovno, zima, unava a tak

ja tedka smeruju k praktikovani lehkyho obeda a pak az snidane dvakrat v tydnu, asi utery a ctvrtek
16-8 sem vydrzel asi dva roky a taky me to sralo )))

hlavne nemas jist vecere, takze muj system, ze sem nesnidal a jedl az pozdni obed byl prej uplne spatne

ale zhubnul jsem, mozna ne zdrave, ale jako za me dobry

NAVARA: No podle dat co rikal, tak od ctyriceti dal zijes na schodech.
A kazdejch par let je schod a cast populace umre.
Kdyz jis malo, tak nejsi na schodech, sle je to lehce sestupna krivka a pak je najednou brutalni schod az dolu.
Takze zijes dyl a ses mnohem zdravejsi a pak se najednou vsechno posere a mas to rychle za sebou.
Zbytek je podle nej prej bullshit.
On dela na vyvoji modernich leku proti rakovine a rikal, ze to je mnohem jednoddusi, nez longevity a stejne na to nejsme schopny prijit. Ze co se tyce lecby nadoru ve tkanich, tak proste spatny. Ze to je hrozne tezkej problem. Organy prej docela dobry uz. Ale vetsi tkane je proste prusvih.

Jsem mel tedka moznost travit cas s jednim molekularnim biologem ze Seattlu.
Bavili jsme se o vsem moznym. A doslo i na longevity.
On pak rika: za dobu, co to mam moznost sledovat, coz je sedesat let, tak mame jen jednu funkcni strategii, a to je kaloricka restrikce.

Na nej cumim, nechapu.

Ale pockej, jak sedesat let, ty si mladsi, nez ja.

Pak mi ukazal ID.

Ja vypadam mlade, lidi mi tipujou tak 33-38 a je mi 44.
On vypadal tak max na ctyricet.

A bylo mu fakt sede.

Rikal, ze to jede od mladi a je to jedina vec, na kterou mame data. Ze vsechbo ostatni funguje tak max v kvasnicich a mozna u mysi.

Mind blown.

TRANCEWARP: no z toho 1. odstavce splnuju temer vsechno az na chlast, ale piju tak jednou za mesic, mozna ani to ne a to treba jeden drink, treba vino nebo pivo a to jeste jakoze s nekym, treba s kamaradkou, sama bych nepila vubec. a cvicit denne, ale chytlo me ted kolo a dlouhodobe rada chodim a urcite cely den nesedim na prdeli, to spis vubec, tak snad ok. :) byla jsem na bodystatu ve stavu vyzranost a rozkydlost po jaru, cekala jsem nejakou hruzu (jako aby me ten priserny vysledek nakopnul, chapes) a vysledky byly prekvapive temer skvele. :)

kazdopadne metformin ted zeru s pauzama a az mi dojde, nakoupim berberin.

a urcite se musim vrhnout do budovani zasoby svalu, precijen je mi 41 a po 50 uz pak naberu leda hovno, to chapu.

jake jsou ted top suplementy vhodne pro zenu po ctyricitce?