MATEEJ: psi jsou, zda se tak trochu, vlci s Williamsovym syndromem
Science on Saturday: Dogs and humans with Williams Syndrome | Princeton Plasma Physics Laboratoryhttps://www.pppl.gov/events/2023/science-saturday-dogs-and-humans-williams-syndromeAbstract: “In 2017, my team discovered that dogs and humans with Williams Syndrome share a handful of genetic variants that both are connected to friendliness. This sharing goes even further where the same genes carry these variants across the two species, indicating a shared common genetic mechanism. Williams Syndrome is diagnosed when people are missing a large chunk of DNA, composed of ~27 genes, and produces a suite of mental and physical traits, which includes a bubbly, extroverted personality. Of these 27 genes, a handful appear to be critical for the Syndrome to manifest and also found to be altered in the most social of dogs and gray wolves when it comes to their distractibility for humans. While dogs are more human-sociable than the average wolf, there is still variation between individual canines. While William Syndrome is due to a large deletion that removes these genes, canines have novel insertions of tiny bits of DNA that work to disrupt those donor genes. Thus we find that both species have the end result of disrupted genetic function of the same genes. We cannot rule out the impact of hundreds of other genes and early life experiences, we find that a small number of genes playing a surprisingly large role in shape social behaviors of dogs and wolves.”